الصفحة الرئيسية

الكلية الجامعية بضباء \ تقنية المختبرات الطبية

محمد طارق محمد شفيع

نسبة اكتمال الملف الشخصي
الجنسية باكستانية
التخصص العام الكيمياء
التخصص الدقيق كيمياء حيوية سريرية
المسمى الوظيفي أستاذ مساعد
الدرجة العلمية (المرتبة) دكتوراه

نبذه مختصرة

To identify novel genes for congenital heart defects using modern genomics Lacking the full spectrum of their genetic architecture and the inability to study beating human cardiac cells in vitro has thwarted advances in the understanding and treatment of cardiac disorders Pediatric cardiomyopathies are clinically heterogeneous heart muscle disorders that are responsible for significant morbidity and mortality Congenital heart defects (CHDs) are structural abnormalities of the heart and great vessels that are present from birth Both genetic and non-genetic factors have been linked to cardiomyopathies and CHD pathogenesis Indeed, more than 100 genes have been identified in cardiomyopathies and CHDs, including troponins (cardiac troponin T type-2 (TNNT2), myosin binding protein C (MYBPC3) and Myosin Heavy Chain (MYH7) and transcriptions factors (ZIC3) I am interested in investigating the cardiomyopathy and CHD families with autosomal recessive inheritance as well as singlet/sporadic cardiomyopathy and CHD cases Sanger sequencing (gene level) and allele-specific PCR (pathogenic variants) of the important cardiomyopathy genes (eg MYH7, and MYBPC3) and CHD genes (ZIC3, NODAL and CFC1) will be performed on the probands of the families and will be followed by exome sequencing Results will be interesting and unique with understanding that detailed genetic architecture has not been investigated in this population The study will be helpful for genetic counseling and follow up disease management

المؤهلات العلمية

PhD MSc

الاهتمامات البحثية

Human and Animal Genetics

الخبرات والمناصب الإدارية

Chairman Committee for Continuous education MLT Chairman Committee for Accreditation Unit Duba MLT

الجدول الدراسي
اليوم المادة الوقت
من إلى
الأحد Biochemistry BCHT201 15:00 17:00
الأحد MLT413 Reserach 20:00 22:00
الإثنين MLT 201 Lab Skills 15:00 17:00
الإثنين MLT405 lab Management 18:00 20:00
الإثنين MLT412 Seminar 20:00 22:00
الثلاثاء MLT301 Clinical Chemistry 1 20:00 21:00
الأربعاء MLT301 Clinical Chemistry 1 20:00 21:00
الخميس MLT301 Clinical Chemistry 1 20:00 21:00
الأبحاث والمؤلفات
  • 1) Stephanie Ware, James D Wilkinson, Muhammad Tariq, Jeffrey A Schubert, Arthi Sridhar, Steven Colan, Ling Shi, Charles Canter, Daphne Hsu, Steven A Webber, Debra Dodd, Melanie Everitt, Paul Kantor, Linda Addonizio, John Jefferies, Joseph Rossano, Elfriede Pahl, Paolo Rusconi, Wendy Chung, Teresa Lee, Jeffrey Towbin, Ashwin Lal, Surbhi Bhatnagar, Bruce Aronow, Phillip Dexheimer, Lisa Martin, Lynn Sleeper, Hiedy Razoky, Jason Czachor, and Steven Lipshultz (2021) Genetic Causes of Cardiomyopathy in Children: First Results from the Pediatric Cardiomyopathy Genes Study Journal of American Heart Association DOI: 101161/JAHA120017731 (In Press-)
  • 2) Mohammad Fahad Ullah, Showket H Bhat, Muhammad Tariq, Faisel M Abuduhier (2019) Clinical Significance of Enzymes in Disease and Diagnosis In: Husain Q, Ullah M (eds) Biocatalysis Springer, Cham pp 213-231 https://doiorg/101007/978-3-030-25023-2_11
  • 6) Jeffrey Schubert, Muhammad Tariq, Gabrielle Geddes, Steven Kindel, Erin M Miller, and Stephanie M Ware (2018) Novel pathogenic variants in filamin C identified in pediatric restrictive cardiomyopathy Human Mutation (IF: 535) 39 (12), 2083-2096
  • 17) Tariq M, Belmont JW, Lalani S, Smolarek T, Ware SM (2011) SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing Genome Biol (IF: 11908) 12:R91
جوائز التميز
المشاريع البحثية
اسم المشروع وصف المشروع
Molecular genetics of Human Heart Defects To identify novel genes for congenital heart defects using modern genomics
Molecular genetics of Human Dilated Cardiomyopathy Accepted and completed 2016-17 and awarded by university of Tabuk
 American Heart Association (AHA) Postdoctoral Fellowship Identification of novel human X-linked heterotaxy genes 12POST10370002 (July 2012-June 2014) Great Rivers Affiliate
معلومات التواصل
البريد الإلكتروني : mshafi@ut.edu.sa